A Novel Coated Pencil-Shaped Graphite Electrode for Potentiometric Determination of Metoclopramide-HCl in Pure and Pharmaceutical Commercial Products
Abstract
The present article aims to determine metoclopramide hydrochloride (MCP) drug by the construction of a coated pencil graphite(CPG) electrode using phosphomolybdic acid (PMA) as an active substance to produce MCPphosphomolybdate ion-pair (MCP-PMA), tributyl phosphate (TBP) as a plasticizer and polyvinyl chloride ( PVC ) as a matrix. The results showed good linearity (1.0 × 10-2 - 1.0 × 10-7) mol.L-1, the slope was 58.486 mV.decade-1 at pH range between 2.8 - 4.7. The detection and quantification limits were 2.1 × 10-7
and 6.9 × 10-7 mol.L-1, the response time was 21 Sec., and the lifetime was 43 days for MCP electrodes. The selectivity coefficient (Kpot ) was also studied for the present electrode in the presence of molecules and other ions with mono, di and tri charges that achieved Kpot values of less than 1 for all investigated species.
The MCP fabricated electrode was applied for determination of the active ingredient in pharmaceutical dosage forms. The recovery percentage range was (99.41-101.39)%.
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