Estimation Cut-off values for ST2 , IGF-1 and GALP in obesity

Abstract

Universal, Obesity is a leading cause of preventable chronic diseases. Both obesity and overweight have increased dramatically in recent years. The liver cells mainly secrete insulin-like growth factor-1 (IGF1), which is an anabolic hormone, and its production and release by the pituitary gland are depending on growth hormone. The soluble interleukin-1 receptor is suppression of tumorigenicity-2 (ST2) that was previously known as the interleukin-1 receptor-like receptor1. A neuropeptide known as galanin-like peptide (GALP) is taking part in the control of energy balance. (2); Materials and methods: The ST2 levels were carried out by using Afias 10 instrument, IGF-1 by Maglumi 800, GALP by Eliza kit, and data Analysis by XLSTATE program. (3) Results; Increase (p<0.002, p<0.001) the level of ST2 in the overweight comparing to normal-weight, and in obese comparing to normal and overweight groups, and a high AUC (0.85) implies a strong correlation between obesity and the ST2 (ng/ml). Decrease (P<0.001, P<0.0013 ) the level of IGF-1 (ng/ml) in obese group  comparing to normal and overweight groups, a strong substantial relation between obesity and IGF-1 (ng/ml) is shown by a high AUC (0.92). Increase (P<0.003, P<0.001) the level of GALP (pg/ml) in obese group  comparing to normal and overweight groups, a strong substantial relation between obesity and GALP (pg/ml) is shown by a high AUC (0.88). (4);Conclusions:  The relationships between ST2, IGF-1, GALP and obesity are close and fundamental. This may be because the accumulated adipose tissue acts as an inflammatory factor that negatively affect.