Analytical comparison between two spectroscopic methods used for the quantitative determination of olanzapine in its pure form
Keywords:
multi-wavelengths, Quantitative determination, olanzapine, analytical comparison, UV-Visible spectrophotometerAbstract
Statistical analysis compared two spectroscopic methods for determining olanzapine in its pure form, revealing similar results. The first method utilized the area under the peak within the wavelength range of 272-308 nm, demonstrating linearity within the range of 0.1-3 µg/ml. Results showed a recovery percentage of 96.05-102.93% and coefficient of variation percentage of 0.007-0.063%. Conversely, the second method employed a multi-wavelength technique at specific wavelengths (276, 284, 292, and 300 nm), with linearity within the range of 0.3-2 µg/ml. Results showed a recovery percentage of 98.6-100.97% and coefficient of variation percentage of 0.009-0.119%. Both methods exhibited sensitivity and accuracy, suggesting their applicability for the precise estimation of olanzapine in laboratory settings focused on quantitative drug analysis.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain copyright and grant the TJHEST journal right of first publication, with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in TJHEST.
The TJHEST permits and encourages authors to archive Pre-print and Post-print items submitted to the journal on personal websites or institutional repositories per the author's choice while providing bibliographic details that credit their submission, and publication in this journal. This includes the archiving of a submitted version, an accepted version, or a published version without any Risks.
