Characteristics of trauma patients with multidrug-resistant bacteria from an epidemiological, clinical, and microbiological perspective

Abstract

Trauma, healthcare-associated infections, and antimicrobial resistance are three major public health issues worldwide due to the high probability of patient morbidity and, ultimately, a tragic outcome. In the current study included all patients admitted to The NRI Medical College Hospital, (Mangalagiri, Andhra Pradesh, India) intensive care units between May 1, 2021 and August 31, 2022. Patients with first bacteremia were found to have MRSA, VRE, and carbapenem-resistant Gram-negative bacteria. We included 1528 patients, 302 of whom had trauma and 66 (4.3%) of whom had MR-agent-induced bacteremia. Mechanical ventilation, renal replacement therapy, and surgery were all independent risk factors for MR agent bacteremia. In the trauma cohort, haemodialysis alone was associated with an increased risk of MR agent bacteremia. S. aureus, MRSA (n=27), and K. pneumoniae (n=26) were the two most common isolating agents. The blaKPC gene was found in 83% of the K. pneumoniae strains (while the NDM gene was found in only one). Injuries have no effect on the development of bacteremia caused by MR agents. Certain risk factors appear to be associated with the severity of MR bacteremia cases.