Measuring levels of Alpha-amylase ,TNF alpha and IL4 in diabetic patients with Periodontitis

Abstract

The current study included collecting samples for the period from February 10, 2023 to June 5, 2023, where 50 samples were collected, 30 samples for patients infected with the E. gingivalis parasite who also had type 2 diabetes, and 20 samples for healthy people selected as a control group from Samarra General Hospital and dental clinics. The levels of tumor necrosis factor alpha, interleukin 4, and alpha amylase were measured in the blood serum using the radioactive enzyme assay technique. The results of the study showed a significant increase in tumor necrosis factor alpha 273.0 ± 24.04 pg/ml in the patient group when compared with control group 58.5 ± 13.18pg/ml, as well as an increase in alpha amylase enzyme levels in the patient group 50.826±6.214pg/ml when compared with control group 30.054±8.424, While the results showed a decrease in the level of interleukin-4 in the patient group0.37±0.108  when compared with control group 0.58±0.107, We conclude from these results that high levels of inflammatory factors have an important role in detecting the extent of disease progression